PIP5KL1

Across TCGA patient cohorts, PIP5KL1 mutation is significantly associated with the RNA expression of many other genes, with 381 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP5KL1-associated genes across cancer lineages are RNA5SP502, RNA5SP418, and LINC01848. Each is linked with PIP5KL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP5KL1-to-partner and partner-to-PIP5KL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP502 grouped by PIP5KL1-low versus PIP5KL1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP5KL1→partner) and Y-score (partner→PIP5KL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP502 →	+0.276	+5.411	.002	.005	3	2
UCEC	RNA5SP418 →	+0.779	+2.377	<.001	.008	3	2
UCEC	LINC01848 →	+0.101	+2.717	<.001	.006	3	2
UCEC	SLC25A4 →	+0.687	+3.470	.002	.003	3	1
UCEC	DBI →	+0.583	+3.234	.005	.008	3	1
UCEC	SH3RF2 →	+0.916	+3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 381 associations by consensus.

RNA5SP502 by PIP5KL1 expression — BLCA

Explore this box plot interactively →