PIP5KL1

Across TCGA cell cohorts, PIP5KL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,159 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PIP5KL1-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Maintenance of protein localization in organelle. Each is linked with PIP5KL1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PIP5KL1-to-partner and partner-to-PIP5KL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by PIP5KL1-low versus PIP5KL1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP5KL1→partner) and Y-score (partner→PIP5KL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of myoblast fusion →	+0.086	+1.400	<.001	<.001	3	12
BONE	Negative regulation of syncytium formation by plasma membrane fusion →	+0.109	+0.998	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Maintenance of protein localization in organelle →	+0.115	+1.318	<.001	.007	3	11
LUNG_NSCLC_LUAD	Regulation of syncytium formation by plasma membrane fusion →	+0.078	+1.352	<.001	<.001	3	11
BONE	Negative regulation of myoblast fusion →	+0.113	+1.025	<.001	<.001	3	11
LARGE_INTESTINE	Regulation of protein modification by small protein conjugation or removal →	+0.055	+1.287	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,159 associations by consensus.

Regulation of myoblast fusion by PIP5KL1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →