Across TCGA pan-cancer cohorts, PIP5K1C Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated PIP5K1C data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIP5K1C Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PIP5K1C expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD and UCEC are the cancer types where PIP5K1C Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.282	0.813	<.001	21	view →
UCEC	DFS	Median	All	0.966	0.632	.023	6	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: PIP5K1C tumor-vs-normal RNA expression · all PIP5K1C data types