Across TCGA pan-cancer cohorts, PIP5K1C mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated PIP5K1C data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIP5K1C mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PIP5K1C expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and CCRCC are the cancer types where PIP5K1C mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.885	0.716	.032	4	view →
PDAC	OS	Median	III,IV	0.871	0.648	.011	4	view →
CCRCC	DFS	Quartile	II,III,IV	0.760	0.391	.035	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: PIP5K1C tumor-vs-normal RNA expression · all PIP5K1C data types