Across TCGA patient cohorts, PIP5K1C mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP5K1C-associated genes across cancer lineages are eIF4E, MEK1, and ATM. Each is linked with PIP5K1C in more than 2 cancer types. Because this analysis shows association rather than direction, both PIP5K1C-to-partner and partner-to-PIP5K1C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP5K1C→partner) and Y-score (partner→PIP5K1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.180	+2.713	.012	.003	3	3
UCEC	MEK1 →	+0.412	+3.000	<.001	<.001	3	3
UCEC	ATM →	-0.544	-2.137	<.001	.001	3	3
UCEC	A-Raf_pS299 →	-0.121	-1.807	.003	.024	3	2
UCEC	S6 →	-0.236	-1.514	.009	.015	3	2
UCEC	SF2 →	-0.141	-1.574	<.001	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Exploration

PIP5K1C survival (RNA) · tumor vs normal (RNA) · all PIP5K1C data types