Across TCGA cell cohorts, PIP5K1C mutation is significantly associated with the RNA expression of many other genes, with 1,053 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIP5K1C-associated genes across cancer lineages are TBC1D21, OR5V1, and COX8C. Each is linked with PIP5K1C in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP5K1C-to-partner and partner-to-PIP5K1C results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP5K1C→partner) and Y-score (partner→PIP5K1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	TBC1D21 →	+0.087	+4.129	<.001	.007	3	2
STOMACH	OR5V1 →	+0.042	+4.285	<.001	.007	3	2
LUNG_NSCLC_LUAD	COX8C →	+0.851	+2.879	<.001	.009	3	2
LARGE_INTESTINE	RIPPLY1 →	+0.370	+3.404	<.001	.001	3	2
LARGE_INTESTINE	FAM160A1 →	+0.887	+3.295	<.001	.003	3	2
LARGE_INTESTINE	ZKSCAN3 →	+0.614	+2.675	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,053 associations by consensus.

Exploration

PIP5K1C survival (RNA) · tumor vs normal (RNA) · all PIP5K1C data types