PIP5K1B

Across TCGA cell cohorts, PIP5K1B mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIP5K1B-associated genes across cancer lineages are TRIM51, MOS, and TSPY4. Each is linked with PIP5K1B in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP5K1B-to-partner and partner-to-PIP5K1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM51 grouped by PIP5K1B-low versus PIP5K1B-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP5K1B→partner) and Y-score (partner→PIP5K1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TRIM51 →	+0.033	+5.614	<.001	.002	3	1
PANCREAS	MOS →	+0.032	+5.000	<.001	.006	3	1
PANCREAS	TSPY4 →	+0.050	+5.614	<.001	.002	3	1
SKIN	CRNN →	+0.063	+4.614	<.001	<.001	3	1
SKIN	OR2T1 →	+0.008	+4.437	<.001	.004	3	1
SKIN	OR1D5 →	+0.014	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

TRIM51 by PIP5K1B expression — PANCREAS

Explore this box plot interactively →