PIP4P2

Across TCGA pan-cancer cohorts, PIP4P2 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PIP4P2’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where PIP4P2 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PIP4P2 is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

LUAD, COAD, and OV are the cancer types where PIP4P2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIP4P2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	−0.436	<.001	9	view →
COAD	Female	All	−0.797	<.001	8	view →
OV	All	All	−0.480	.029	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PIP4P2–LUAD

Open the LUAD breakdown →