PIP4P2

Across TCGA patient cohorts, PIP4P2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP4P2-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and ERK2. Each is linked with PIP4P2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP4P2-to-partner and partner-to-PIP4P2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PIP4P2-low versus PIP4P2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4P2→partner) and Y-score (partner→PIP4P2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.099	-1.893	.014	.016	3	1
UCEC	A-Raf_pS299 →	-0.172	-2.415	<.001	.003	3	1
UCEC	ERK2 →	+0.186	+2.415	.016	.003	3	1
UCEC	IGFBP2 →	-0.649	-2.459	.013	.019	3	1
UCEC	JNK2 →	+0.250	+2.196	.001	.032	3	1
UCEC	Ku80 →	+0.193	+2.428	.042	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

14-3-3_beta by PIP4P2 expression — UCEC

Explore this box plot interactively →