PIP4P1

Across TCGA pan-cancer cohorts, PIP4P1 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIP4P1 data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher PIP4P1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIP4P1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

THYM, LIHC, and BLCA are the cancer types where PIP4P1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	DFS	Median	All	0.123	0.871	<.001	12	view →
LIHC	DFS	Median	All	0.044	0.553	<.001	9	view →
BLCA	DFS	Median	All	0.163	0.519	.029	6	view →
UCEC	DFS	Median	All	1.000	0.635	.032	4	view →
LUAD	OS	Median	All	0.276	0.697	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIP4P1–THYM (DFS)

Open the THYM breakdown →