PIP4P1

Across TCGA pan-cancer cohorts, PIP4P1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIP4P1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PIP4P1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIP4P1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and CCRCC are the cancer types where PIP4P1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.231	0.818	.001	36	view →
LSCC	OS	Median	II,III,IV	0.962	0.747	.003	32	view →
CCRCC	OS	Quartile	All	0.812	1.000	.009	9	view →
UCEC	OS	Median	II,III,IV	0.647	1.000	.017	4	view →
LUAD	OS	Quartile	II,III,IV	1.000	0.367	.024	3	view →
PDAC	OS	Median	IV	0.937	0.395	.026	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIP4P1–HNSC (DFS)

Open the HNSC breakdown →