PIP4P1

Across TCGA patient cohorts, PIP4P1 mutation is significantly associated with the RNA expression of many other genes, with 487 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP4P1-associated genes across cancer lineages are TRAJ5, OR2Z1, and OR5G5P. Each is linked with PIP4P1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP4P1-to-partner and partner-to-PIP4P1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAJ5 grouped by PIP4P1-low versus PIP4P1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4P1→partner) and Y-score (partner→PIP4P1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRAJ5 →	+0.880	+2.385	<.001	<.001	3	2
CESC	OR2Z1 →	+0.046	+5.103	<.001	.008	3	1
CESC	OR5G5P →	+0.110	+5.201	<.001	.007	3	1
CESC	DNAJA1P1 →	+0.047	+5.306	<.001	.006	3	1
CESC	LINC01442 →	+0.025	+5.669	<.001	.003	3	1
CESC	HNRNPH3P1 →	+0.086	+5.010	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 487 associations by consensus.

TRAJ5 by PIP4P1 expression — UCEC

Explore this box plot interactively →