PIP4K2A

Across TCGA pan-cancer cohorts, PIP4K2A Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIP4K2A data layer compared with 25 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PIP4K2A Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated PIP4K2A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, UCEC, and LUSC are the cancer types where PIP4K2A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.121	0.829	<.001	42	view →
UCEC	DFS	Median	All	0.965	0.624	.013	16	view →
LUSC	OS	Median	All	0.196	0.724	.049	3	view →
SKCM	OS	Median	All	0.556	0.878	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIP4K2A–CESC (OS)

Open the CESC breakdown →