PIP4K2A

Across TCGA pan-cancer cohorts, PIP4K2A mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIP4K2A data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PIP4K2A mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PIP4K2A expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, LSCC, and PDAC are the cancer types where PIP4K2A mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.920	0.597	<.001	37	view →
LSCC	DFS	Median	All	0.869	1.000	.003	32	view →
PDAC	DFS	Quartile	III,IV	1.000	0.404	.004	13	view →
UCEC	DFS	Tertile	III,IV	0.352	1.000	.013	12	view →
LUAD	DFS	Tertile	III,IV	0.456	0.863	.024	6	view →
HNSC	DFS	Median	II,III,IV	0.906	0.983	.029	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIP4K2A–CCRCC (DFS)

Open the CCRCC breakdown →