PIP4K2A

Across TCGA patient cohorts, PIP4K2A mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIP4K2A-associated genes across cancer lineages are ACC_pS79, GAPDH, and INPP4B. Each is linked with PIP4K2A in more than 1 cancer types. Because this analysis shows association rather than direction, both PIP4K2A-to-partner and partner-to-PIP4K2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACC_pS79 grouped by PIP4K2A-low versus PIP4K2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4K2A→partner) and Y-score (partner→PIP4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.244	+1.736	.043	.007	3	2
UCEC	GAPDH →	+0.466	+2.584	.012	.010	3	2
UCEC	INPP4B →	-0.320	-2.906	.004	.001	3	2
UCEC	RAD51 →	+0.131	+2.321	.007	.005	3	2
UCEC	Shc_pY317 →	-0.175	-2.000	<.001	.029	3	2
UCEC	eEF2 →	+0.342	+1.736	.005	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

ACC_pS79 by PIP4K2A expression — UCEC

Explore this box plot interactively →