PIP4K2A

Across TCGA cell cohorts, PIP4K2A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,123 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PIP4K2A-associated GO terms across cancer lineages are 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process, and Megakaryocyte differentiation. Each is linked with PIP4K2A in more than 15 cancer types. Because this analysis shows association rather than direction, both PIP4K2A-to-partner and partner-to-PIP4K2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process grouped by PIP4K2A-low versus PIP4K2A-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIP4K2A→partner) and Y-score (partner→PIP4K2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process →	+0.190	+1.439	<.001	.001	3	16
KIDNEY	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process →	+0.145	+0.885	<.001	.002	3	14
LIVER	Megakaryocyte differentiation →	+0.190	+1.178	.002	.001	3	14
SKIN	Vesicle-mediated cholesterol transport →	+0.130	+1.170	<.001	<.001	3	12
BONE	Endothelial cell fate commitment →	+0.202	+0.879	.003	.007	3	11
BONE	Regulation of angiotensin-activated signaling pathway →	+0.251	+0.907	<.001	.009	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,123 associations by consensus.

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process by PIP4K2A expression — STOMACH

Explore this box plot interactively →