PINK1

Across TCGA patient cohorts, PINK1 mutation is significantly associated with the RNA expression of many other genes, with 662 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PINK1-associated genes across cancer lineages are RNU6-358P, SPATA31E3P, and TRAJ34. Each is linked with PINK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both PINK1-to-partner and partner-to-PINK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-358P grouped by PINK1-low versus PINK1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PINK1→partner) and Y-score (partner→PINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNU6-358P →	+0.507	+4.548	<.001	.009	3	3
OV	SPATA31E3P →	+0.006	+5.572	.002	.004	3	2
CESC	TRAJ34 →	+0.594	+4.101	.008	.004	3	2
UCEC	RNA5SP411 →	+1.044	+2.223	<.001	.002	3	2
BRCA	RNA5SP125 →	+0.331	+6.133	<.001	.001	3	2
BRCA	RPS10P21 →	+0.131	+6.026	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 662 associations by consensus.

RNU6-358P by PINK1 expression — LUSC

Explore this box plot interactively →