PINK1

Across TCGA cell cohorts, PINK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,619 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PINK1-associated GO terms across cancer lineages are Cellular response to hydrogen sulfide, Response to hydrogen sulfide, and Positive regulation of cristae formation. Each is linked with PINK1 in more than 19 cancer types. Because this analysis shows association rather than direction, both PINK1-to-partner and partner-to-PINK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cellular response to hydrogen sulfide grouped by PINK1-low versus PINK1-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PINK1→partner) and Y-score (partner→PINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Cellular response to hydrogen sulfide →	+1.169	+2.693	<.001	<.001	3	20
KIDNEY	Response to hydrogen sulfide →	+1.234	+2.004	<.001	<.001	3	20
KIDNEY	Positive regulation of cristae formation →	+0.220	+1.317	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Mitochondrion to lysosome vesicle-mediated transport →	+0.316	+1.811	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Mitochondrion-derived vesicle mediated transport →	+0.316	+1.811	<.001	<.001	3	19
STOMACH	Autophagy of mitochondrion →	+0.113	+1.942	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,619 associations by consensus.

Cellular response to hydrogen sulfide by PINK1 expression — STOMACH

Explore this box plot interactively →