PINK1

Across TCGA cell cohorts, PINK1 mutation is significantly associated with the RNA expression of many other genes, with 39 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PINK1-associated genes across cancer lineages are IL3, CD300H, and KRTAP4-4. Each is linked with PINK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PINK1-to-partner and partner-to-PINK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL3 grouped by PINK1-low versus PINK1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PINK1→partner) and Y-score (partner→PINK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	IL3 →	+0.014	+4.196	<.001	.006	3	2
LARGE_INTESTINE	CD300H →	+0.024	+3.415	<.001	.001	3	2
BLOOD_Myeloma	KRTAP4-4 →	+0.030	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KRTAP12-1 →	+0.066	+4.807	<.001	.006	3	1
BLOOD_Myeloma	KIR2DS4 →	+0.023	+4.807	<.001	.006	3	1
BREAST	C8B →	+0.008	+4.196	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

IL3 by PINK1 expression — BREAST

Explore this box plot interactively →