PIN4

Across TCGA pan-cancer cohorts, PIN4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated PIN4 data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher PIN4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated PIN4 expression acts as an unfavorable survival marker, although some lineages such as COAD and LUAD show a favorable association.

COAD, OV, and LUAD are the cancer types where PIN4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.020	18	view →
OV	DFS	Tertile	All	0.523	1.000	.028	12	view →
LUAD	OS	Tertile	All	0.931	0.577	.011	7	view →
PDAC	OS	Median	IV	0.491	0.836	.024	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

PIN4–COAD (DFS)

Open the COAD breakdown →