PIN4

Across TCGA patient cohorts, PIN4 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIN4-associated genes across cancer lineages are Gab2, Src, and VHL. Each is linked with PIN4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIN4-to-partner and partner-to-PIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by PIN4-low versus PIN4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIN4→partner) and Y-score (partner→PIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.501	+3.169	.010	.020	3	1
UCEC	Src →	-0.388	-3.169	<.001	.019	3	1
UCEC	VHL →	-1.207	-3.169	.001	.020	3	1
UCEC	ERK2 →	+0.269	+3.169	.011	.020	1	1
UCEC	NDRG1_pT346 →	-0.686	-3.169	.010	.020	1	1
UCEC	Cyclin-E2 →	+0.193	+3.169	.037	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Gab2 by PIN4 expression — UCEC

Explore this box plot interactively →