PIN4

Across TCGA cell cohorts, PIN4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,766 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIN4-associated GO terms across cancer lineages are Spliceosomal tri-snRNP complex assembly, RNA splicing, via transesterification reactions, and RNA splicing, via transesterification reactions with bulged adenosine as nucleophile. Each is linked with PIN4 in more than 11 cancer types. Because this analysis shows association rather than direction, both PIN4-to-partner and partner-to-PIN4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spliceosomal tri-snRNP complex assembly grouped by PIN4-low versus PIN4-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIN4→partner) and Y-score (partner→PIN4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Spliceosomal tri-snRNP complex assembly →	+0.098	+0.793	.008	.008	3	12
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions →	+0.068	+0.836	.003	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.067	+0.792	.003	.001	3	12
UPPER_AERODIGESTIVE_TRACT	mRNA splicing, via spliceosome →	+0.067	+0.792	.003	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Spliceosomal conformational changes to generate catalytic conformation →	+0.068	+0.541	<.001	.002	3	10
UPPER_AERODIGESTIVE_TRACT	Protein-DNA complex assembly →	+0.055	+0.732	.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,766 associations by consensus.

Spliceosomal tri-snRNP complex assembly by PIN4 expression — STOMACH

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