PIN1

Across TCGA pan-cancer cohorts, PIN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIN1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher PIN1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated PIN1 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, LSCC, and HNSC are the cancer types where PIN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	All	0.937	0.741	.006	49	view →
LSCC	DFS	Median	II,III,IV	1.000	0.849	.001	22	view →
HNSC	DFS	Quartile	IV	0.563	0.921	.001	12	view →
PDAC	DFS	Quartile	All	0.896	0.695	.013	12	view →
GBM	DFS	Tertile	All	0.227	0.446	.028	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIN1–CCRCC (OS)

Open the CCRCC breakdown →