PIN1

Across TCGA patient cohorts, PIN1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,968 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIN1-associated genes across cancer lineages are FBXL12, ECSIT, and UBL5. Each is linked with PIN1 in more than 5 cancer types. Because this analysis shows association rather than direction, both PIN1-to-partner and partner-to-PIN1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIN1 versus FBXL12 in OV, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIN1→partner) and Y-score (partner→PIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	FBXL12 →	+0.565	+0.445	<.001	<.001	3	6
OV	ECSIT →	+0.687	+0.401	<.001	<.001	3	6
OV	UBL5 →	+0.670	+0.471	<.001	<.001	3	6
OV	ZNF627 →	+0.696	+0.522	.001	<.001	3	6
OV	ILF3-DT →	+0.603	+0.450	<.001	<.001	3	6
GBM	MTURN →	+1.229	+0.283	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,968 associations by consensus.

PIN1 vs FBXL12 — OV

Explore this scatter interactively →