PIN1

Across TCGA cell cohorts, PIN1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,473 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIN1-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Regulation of protein localization to chromatin, and Energy coupled proton transmembrane transport, against electrochemical gradient. Each is linked with PIN1 in more than 18 cancer types. Because this analysis shows association rather than direction, both PIN1-to-partner and partner-to-PIN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by PIN1-low versus PIN1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIN1→partner) and Y-score (partner→PIN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.169	+0.668	<.001	.001	3	19
BONE	Regulation of protein localization to chromatin →	+0.128	+0.667	.001	.001	3	17
PANCREAS	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.085	+0.757	<.001	.003	3	16
PANCREAS	Electron transport coupled proton transport →	+0.085	+0.757	<.001	.003	3	16
BONE	Regulation of anaphase-promoting complex-dependent catabolic process →	+0.200	+0.773	<.001	<.001	3	16
PANCREAS	Spindle elongation →	+0.201	+0.603	<.001	.006	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,473 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by PIN1 expression — BONE

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