PIMREG

Across TCGA pan-cancer cohorts, PIMREG RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PIMREG’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PIMREG RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIMREG is over-expressed in tumor.

BLCA, HNSC, and LUAD are the cancer types where PIMREG tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIMREG RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	All	+2.712	<.001	12	view →
HNSC	Male	III,IV	+2.196	<.001	12	view →
LUAD	All	IV	+3.590	<.001	11	view →
KIRP	All	III,IV	+1.958	<.001	11	view →
KIRC	Male	IV	+1.385	<.001	11	view →
COAD	Female	II,III,IV	+1.473	<.001	10	view →
LUSC	Female	All	+3.274	<.001	9	view →
STAD	All	II,III,IV	+1.859	<.001	9	view →
THCA	Male	All	+0.656	<.001	9	view →
UCEC	All	III,IV	+3.466	<.001	8	view →
LIHC	Female	All	+0.795	<.001	8	view →
BRCA	All	III,IV	+1.848	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PIMREG–BLCA

Open the BLCA breakdown →