PIMREG

Across TCGA pan-cancer cohorts, PIMREG mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of PIMREG’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIMREG mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types PIMREG is over-expressed in tumor, although a few such as LUAD show the opposite, repressed pattern.

HNSC, LSCC, and LUAD are the cancer types where PIMREG tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIMREG mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+2.337	<.001	8	view →
LSCC	Male	All	+1.557	<.001	8	view →
LUAD	Female	All	−0.463	<.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

PIMREG–HNSC

Open the HNSC breakdown →