Across TCGA patient cohorts, PIM3 mutation is significantly associated with the RNA expression of many other genes, with 176 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIM3-associated genes across cancer lineages are RN7SL447P, LINC00644, and RPS28P1. Each is linked with PIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIM3-to-partner and partner-to-PIM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIM3→partner) and Y-score (partner→PIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL447P →	+0.111	+4.385	<.001	.008	3	2
BLCA	LINC00644 →	+0.263	+5.497	.002	.004	3	1
BLCA	RPS28P1 →	+0.219	+5.329	.003	.006	3	1
BLCA	MIR6842 →	+0.651	+5.177	<.001	.007	3	1
UCEC	MIR8082 →	+0.492	+3.076	<.001	.001	3	1
UCEC	RPS29P32 →	+0.449	+3.114	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 176 associations by consensus.

Exploration

PIM3 survival (RNA) · tumor vs normal (RNA) · all PIM3 data types