Across TCGA patient cohorts, PIM3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIM3-associated genes across cancer lineages are GSK-3_pS9, Akt_pS473, and AMPK_pT172. Each is linked with PIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIM3-to-partner and partner-to-PIM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIM3→partner) and Y-score (partner→PIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3_pS9 →	+0.697	+3.000	.002	.037	3	1
UCEC	Akt_pS473 →	+1.254	+3.000	.002	.037	3	1
UCEC	AMPK_pT172 →	+0.494	+3.013	.037	.019	3	1
UCEC	Tuberin_pT1462 →	+0.438	+3.009	.001	.019	3	1
UCEC	Tuberin →	+0.359	+3.000	.021	.037	3	1
UCEC	Akt_pT308 →	+1.119	+3.000	.002	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

PIM3 survival (RNA) · tumor vs normal (RNA) · all PIM3 data types