PIM3

RNA expression — cross-omics
Cross-omicsRNA → FUNCTION-RNACell-linePairwise association · TCGA cohorts

Across TCGA cell cohorts, PIM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,878 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible PIM3-associated GO terms across cancer lineages are Response to forskolin, Negative regulation of autophagy, and Positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Each is linked with PIM3 in more than 11 cancer types. Because this analysis shows association rather than direction, both PIM3-to-partner and partner-to-PIM3 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIM3→partner) and Y-score (partner→PIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner GO termX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UPPER_AERODIGESTIVE_TRACTResponse to forskolin →+0.189+0.756<.001<.001312
LIVERNegative regulation of autophagy →+0.063+0.717.004.00239
BLOOD_LymphomaPositive regulation of proteasomal ubiquitin-dependent protein catabolic process →+0.079+1.287<.001<.00139
BONECytoplasm protein quality control by the ubiquitin-proteasome system →+0.148+1.226<.001<.00139
BONERegulation of mitophagy →+0.094+1.105<.001.00939
BONETranscription pausing by RNA polymerase II →+0.158+1.501<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,878 associations by consensus.

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