Across TCGA cell cohorts, PIM3 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PIM3-associated genes across cancer lineages are SPINT4, SPACA5B, and OR4F4. Each is linked with PIM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIM3-to-partner and partner-to-PIM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIM3→partner) and Y-score (partner→PIM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPINT4 →	+0.058	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	SPACA5B →	+0.035	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	OR4F4 →	+0.006	+4.887	.009	.009	3	1
LARGE_INTESTINE	ARMH2 →	+0.277	+4.930	<.001	.001	3	1
LARGE_INTESTINE	OTOP3 →	+0.047	+4.301	<.001	.005	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Exploration

PIM3 survival (RNA) · tumor vs normal (RNA) · all PIM3 data types