PIM2

Across TCGA patient cohorts, PIM2 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIM2-associated genes across cancer lineages are p53, ASNS, and Chk2_pT68. Each is linked with PIM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIM2-to-partner and partner-to-PIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p53 grouped by PIM2-low versus PIM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIM2→partner) and Y-score (partner→PIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p53 →	-0.382	-2.999	.034	.035	3	2
UCEC	ASNS →	+0.522	+2.459	.001	.019	2	3
UCEC	Chk2_pT68 →	-0.182	-3.143	.035	.018	3	2
UCEC	14-3-3_beta →	-0.137	-3.687	.003	.001	3	1
UCEC	Heregulin →	-0.172	-2.986	.002	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.167	-3.000	.033	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

p53 by PIM2 expression — UCEC

Explore this box plot interactively →