PIM2

Across TCGA cell cohorts, PIM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,447 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIM2-associated GO terms across cancer lineages are Growth hormone secretion, Porphyrin-containing compound biosynthetic process, and Tetrapyrrole biosynthetic process. Each is linked with PIM2 in more than 10 cancer types. Because this analysis shows association rather than direction, both PIM2-to-partner and partner-to-PIM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Growth hormone secretion grouped by PIM2-low versus PIM2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIM2→partner) and Y-score (partner→PIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Growth hormone secretion →	+0.110	+0.733	<.001	.004	3	11
BLOOD_Leukemia	Porphyrin-containing compound biosynthetic process →	+0.089	+1.132	<.001	.007	3	10
BLOOD_Leukemia	Tetrapyrrole biosynthetic process →	+0.089	+1.132	<.001	.007	3	10
UPPER_AERODIGESTIVE_TRACT	Positive regulation of translation →	+0.057	+0.754	.007	.002	3	10
SKIN	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.129	+0.928	<.001	<.001	3	9
OVARY	Regulation of synapse structural plasticity →	+1.218	+0.725	<.001	.003	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,447 associations by consensus.

Growth hormone secretion by PIM2 expression — BREAST

Explore this box plot interactively →