PIM1

Across TCGA cell cohorts, PIM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,819 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible PIM1-associated GO terms across cancer lineages are Positive regulation of cell proliferation involved in heart morphogenesis, Regulation of hematopoietic stem cell proliferation, and Regulation of cell proliferation involved in heart morphogenesis. Each is linked with PIM1 in more than 17 cancer types. Because this analysis shows association rather than direction, both PIM1-to-partner and partner-to-PIM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of cell proliferation involved in heart morphogenesis grouped by PIM1-low versus PIM1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIM1→partner) and Y-score (partner→PIM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of cell proliferation involved in heart morphogenesis →	+0.218	+1.391	<.001	<.001	3	18
BREAST	Regulation of hematopoietic stem cell proliferation →	+0.222	+1.957	<.001	<.001	3	16
LUNG_SCLC	Regulation of cell proliferation involved in heart morphogenesis →	+0.183	+1.232	<.001	<.001	3	16
BREAST	Regulation of cardioblast proliferation →	+0.989	+1.787	<.001	<.001	3	15
STOMACH	Hormone-mediated signaling pathway →	+0.075	+1.292	<.001	.003	3	14
STOMACH	Nuclear receptor-mediated signaling pathway →	+0.107	+1.688	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,819 associations by consensus.

Positive regulation of cell proliferation involved in heart morphogenesis by PIM1 expression — LUNG_SCLC

Explore this box plot interactively →