PILRA

Across TCGA patient cohorts, PILRA mutation is significantly associated with the RNA expression of many other genes, with 1,258 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PILRA-associated genes across cancer lineages are RPL22P4, LINC02502, and LINC01992. Each is linked with PILRA in more than 2 cancer types. Because this analysis shows association rather than direction, both PILRA-to-partner and partner-to-PILRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL22P4 grouped by PILRA-low versus PILRA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PILRA→partner) and Y-score (partner→PILRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPL22P4 →	+0.083	+2.111	.003	.009	3	3
CESC	LINC02502 →	+1.100	+4.996	<.001	.002	3	2
CESC	LINC01992 →	+0.377	+4.409	.008	.006	3	2
CESC	NEK2P2 →	+0.065	+4.539	<.001	.008	3	2
LUAD	RPL21P66 →	+0.122	+4.962	<.001	.002	3	2
COAD	RN7SKP66 →	+0.245	+6.142	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,258 associations by consensus.

RPL22P4 by PILRA expression — SKCM

Explore this box plot interactively →