PILRA

Across TCGA patient cohorts, PILRA mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PILRA-associated genes across cancer lineages are Caveolin-1, ATM, and c-Jun_pS73. Each is linked with PILRA in more than 1 cancer types. Because this analysis shows association rather than direction, both PILRA-to-partner and partner-to-PILRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caveolin-1 grouped by PILRA-low versus PILRA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PILRA→partner) and Y-score (partner→PILRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Caveolin-1 →	-0.730	-3.000	.039	.036	3	1
UCEC	ATM →	-0.567	-3.000	.030	.036	3	1
SKCM	c-Jun_pS73 →	+0.186	+3.017	.018	.019	2	1
UCEC	Gab2 →	+0.500	+3.000	.015	.037	2	1
UCEC	Notch1 →	+0.324	+3.000	<.001	.037	2	1
UCEC	Bak →	+0.288	+3.000	.046	.037	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Caveolin-1 by PILRA expression — SKCM

Explore this box plot interactively →