Across TCGA pan-cancer cohorts, PIK3R4 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIK3R4 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PIK3R4 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated PIK3R4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC, SARC, and COAD are the cancer types where PIK3R4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.951	0.604	.003	30	view →
SARC	OS	Median	All	0.151	0.745	.001	12	view →
COAD	OS	Median	All	0.576	0.805	.010	10	view →
SCLC	OS	Median	All	0.274	0.711	.019	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: PIK3R4 tumor-vs-normal RNA expression · all PIK3R4 data types