Across TCGA pan-cancer cohorts, PIK3R4 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIK3R4 data layer compared with 26 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher PIK3R4 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIK3R4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

UCEC, LUAD, and LSCC are the cancer types where PIK3R4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.767	0.981	.001	26	view →
LUAD	DFS	Median	All	0.933	0.869	.006	14	view →
LSCC	DFS	Median	All	0.991	0.560	.016	4	view →
HNSC	OS	Median	All	1.000	0.958	.020	4	view →
PDAC	OS	Tertile	II,III,IV	0.751	0.975	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: PIK3R4 tumor-vs-normal RNA expression · all PIK3R4 data types