Across TCGA patient cohorts, PIK3R4 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,797 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIK3R4-associated proteins across cancer lineages are UBXN7, CELF1, and DBR1. Each is linked with PIK3R4 in more than 5 cancer types. Because this analysis shows association rather than direction, both PIK3R4-to-partner and partner-to-PIK3R4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R4→partner) and Y-score (partner→PIK3R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	UBXN7 →	+0.438	+0.645	<.001	<.001	3	6
LSCC	CELF1 →	+0.280	+0.595	<.001	<.001	3	6
LSCC	DBR1 →	+0.341	+0.662	<.001	<.001	3	6
LSCC	GMPS →	+0.444	+0.592	<.001	<.001	3	6
HNSC	ZNF148 →	+0.429	+0.927	<.001	<.001	3	5
LSCC	PCNA →	+0.503	+0.482	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,797 associations by consensus.

Exploration

PIK3R4 survival (RNA) · tumor vs normal (RNA) · all PIK3R4 data types