Across TCGA patient cohorts, PIK3R4 protein abundance is significantly associated with the RNA expression of many other genes, with 6,004 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PIK3R4-associated genes across cancer lineages are CDV3, SIGLEC8, and UVRAG. Each is linked with PIK3R4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3R4-to-partner and partner-to-PIK3R4 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R4→partner) and Y-score (partner→PIK3R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CDV3 →	+0.471	+0.167	<.001	<.001	3	4
LSCC	SIGLEC8 →	+0.689	+0.121	<.001	.001	3	3
OV	UVRAG →	+0.686	+0.229	.001	<.001	3	3
OV	TIMMDC1 →	+0.410	+0.171	.003	.001	3	3
UCEC	NAA35 →	-0.418	-0.167	.001	.003	3	3
BRCA	GTF2E1 →	+0.375	+0.186	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,004 associations by consensus.

Exploration

PIK3R4 survival (RNA) · tumor vs normal (RNA) · all PIK3R4 data types