Across TCGA patient cohorts, PIK3R4 mutation is significantly associated with the RNA expression of many other genes, with 3,946 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3R4-associated genes across cancer lineages are TPM4P1, MCM6, and RNU6-726P. Each is linked with PIK3R4 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3R4-to-partner and partner-to-PIK3R4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R4→partner) and Y-score (partner→PIK3R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TPM4P1 →	+0.088	+5.074	<.001	<.001	3	4
UCEC	MCM6 →	+0.409	+1.415	.005	.002	3	4
CESC	RNU6-726P →	+0.223	+3.507	.001	.005	3	3
UCEC	RNA5SP411 →	+0.785	+1.442	<.001	.001	3	3
UCEC	TOMM22 →	+0.341	+1.786	<.001	<.001	3	3
UCEC	CEP76 →	+0.294	+2.021	.003	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,946 associations by consensus.

Exploration

PIK3R4 survival (RNA) · tumor vs normal (RNA) · all PIK3R4 data types