Across TCGA patient cohorts, PIK3R4 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3R4-associated genes across cancer lineages are ATM, mTOR_pS2448, and Gab2. Each is linked with PIK3R4 in more than 4 cancer types. Because this analysis shows association rather than direction, both PIK3R4-to-partner and partner-to-PIK3R4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R4→partner) and Y-score (partner→PIK3R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.653	-2.369	<.001	<.001	3	5
UCEC	mTOR_pS2448 →	-0.111	-1.342	.011	.034	3	3
UCEC	Gab2 →	+0.231	+1.058	.028	.037	3	2
UCEC	GATA6 →	-0.133	-2.400	.004	.002	3	2
UCEC	JNK2 →	+0.226	+2.114	<.001	.002	3	2
UCEC	Rab25 →	-0.312	-1.584	.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

Exploration

PIK3R4 survival (RNA) · tumor vs normal (RNA) · all PIK3R4 data types