Across TCGA cell cohorts, PIK3R4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,622 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3R4-associated GO terms across cancer lineages are Regulation of centriole replication, DNA replication, and DNA recombination. Each is linked with PIK3R4 in more than 10 cancer types. Because this analysis shows association rather than direction, both PIK3R4-to-partner and partner-to-PIK3R4 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R4→partner) and Y-score (partner→PIK3R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of centriole replication →	+0.065	+0.476	<.001	.009	3	11
BLOOD_Myeloma	DNA replication →	+0.090	+0.684	.002	.003	3	11
LUNG_NSCLC_LUSC	DNA recombination →	+0.055	+0.627	.006	.008	3	10
LUNG_NSCLC_LUSC	Protein localization to chromosome →	+0.083	+0.667	.006	.001	3	10
LUNG_NSCLC_LUSC	Double-strand break repair →	+0.055	+0.860	.001	<.001	3	9
LUNG_NSCLC_LUSC	Double-strand break repair via nonhomologous end joining →	+0.055	+0.765	.002	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,622 associations by consensus.

Exploration

PIK3R4 survival (RNA) · tumor vs normal (RNA) · all PIK3R4 data types