Across TCGA cell cohorts, PIK3R4 mutation is significantly associated with the RNA expression of many other genes, with 169 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3R4-associated genes across cancer lineages are SIGLEC5, PTF1A, and EFCAB3. Each is linked with PIK3R4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R4-to-partner and partner-to-PIK3R4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R4→partner) and Y-score (partner→PIK3R4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SIGLEC5 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	PTF1A →	+0.346	+4.906	<.001	.006	3	1
OESOPHAGUS	EFCAB3 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	OR6X1 →	+0.020	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUSC	GHRHR →	+0.176	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 169 associations by consensus.

Exploration

PIK3R4 survival (RNA) · tumor vs normal (RNA) · all PIK3R4 data types