PIK3R2

Across TCGA pan-cancer cohorts, PIK3R2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIK3R2 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PIK3R2 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIK3R2 expression acts as an unfavorable survival marker.

ACC, PRAD, and BLCA are the cancer types where PIK3R2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.046	0.753	<.001	36	view →
PRAD	OS	Median	All	0.080	0.990	<.001	12	view →
BLCA	OS	Median	IV	0.214	0.602	.010	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	OS	Median	All	0.436	0.662	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIK3R2–ACC (DFS)

Open the ACC breakdown →