PIK3R1

Across TCGA pan-cancer cohorts, PIK3R1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated PIK3R1 data layer compared with 26 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher PIK3R1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3R1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUAD, UCEC, and GBM are the cancer types where PIK3R1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.722	0.998	.009	14	view →
UCEC	DFS	Median	All	0.936	0.787	.014	6	view →
GBM	DFS	Median	All	0.239	0.487	.004	6	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	4	view →
CCRCC	DFS	Quartile	III,IV	0.255	0.760	.007	2	view →
PDAC	OS	Tertile	III,IV	0.526	1.000	.022	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

PIK3R1–LUAD (OS)

Open the LUAD breakdown →