PIK3R1

Across TCGA patient cohorts, PIK3R1 protein abundance is significantly associated with the RNA expression of many other genes, with 13,697 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PIK3R1-associated genes across cancer lineages are CD37, WDFY4, and WAS. Each is linked with PIK3R1 in more than 8 cancer types. Because this analysis shows association rather than direction, both PIK3R1-to-partner and partner-to-PIK3R1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3R1 versus CD37 in OV, with a Pearson correlation of 0.51.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R1→partner) and Y-score (partner→PIK3R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD37 →	+0.928	+0.295	<.001	.004	3	9
OV	WDFY4 →	+1.046	+0.457	<.001	<.001	3	9
OV	WAS →	+0.978	+0.374	<.001	<.001	3	9
OV	ARHGAP30 →	+1.048	+0.457	<.001	<.001	3	9
GBM	LYL1 →	+0.687	+0.246	<.001	<.001	3	8
OV	RASAL3 →	+0.988	+0.441	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,697 associations by consensus.

PIK3R1 vs CD37 — OV

Explore this scatter interactively →