PIK3R1

Across TCGA cell cohorts, PIK3R1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,832 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3R1-associated GO terms across cancer lineages are Regulation of focal adhesion disassembly, Response to insulin, and Insulin-like growth factor receptor signaling pathway. Each is linked with PIK3R1 in more than 11 cancer types. Because this analysis shows association rather than direction, both PIK3R1-to-partner and partner-to-PIK3R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of focal adhesion disassembly grouped by PIK3R1-low versus PIK3R1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R1→partner) and Y-score (partner→PIK3R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of focal adhesion disassembly →	+0.127	+1.568	.003	.009	3	12
SOFT_TISSUE	Response to insulin →	+0.044	+1.742	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Insulin-like growth factor receptor signaling pathway →	+0.113	+1.225	<.001	<.001	3	12
SKIN	Cellular response to insulin stimulus →	+0.044	+0.881	<.001	<.001	3	11
URINARY_TRACT	Phosphatidylinositol 3-kinase/protein kinase B signal transduction →	+0.115	+1.445	<.001	.004	3	11
UPPER_AERODIGESTIVE_TRACT	Glycerophospholipid biosynthetic process →	+0.056	+1.250	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,832 associations by consensus.

Regulation of focal adhesion disassembly by PIK3R1 expression — LIVER

Explore this box plot interactively →