PIK3R1

Across TCGA cell cohorts, PIK3R1 mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3R1-associated genes across cancer lineages are PRR23A, LUZP4, and OR10A5. Each is linked with PIK3R1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R1-to-partner and partner-to-PIK3R1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23A grouped by PIK3R1-low versus PIK3R1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R1→partner) and Y-score (partner→PIK3R1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRR23A →	+0.063	+3.058	<.001	.004	3	2
OVARY	LUZP4 →	+0.034	+3.736	.002	.002	3	1
OVARY	OR10A5 →	+0.018	+2.859	.003	.008	3	1
OVARY	XAGE3 →	+0.119	+3.855	.006	.001	3	1
OVARY	XAGE5 →	+0.144	+3.781	<.001	.001	3	1
OVARY	CCR9 →	+0.074	+3.906	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

PRR23A by PIK3R1 expression — OVARY

Explore this box plot interactively →