PIK3IP1

Across TCGA pan-cancer cohorts, PIK3IP1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated PIK3IP1 data layer compared with 24 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher PIK3IP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIK3IP1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where PIK3IP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.303	1.000	<.001	21	view →
PDAC	OS	Tertile	II,III,IV	0.861	0.272	.024	9	view →
LUAD	DFS	Tertile	II,III,IV	0.701	0.976	.017	5	view →
HNSC	DFS	Median	All	0.839	0.405	.043	4	view →
GBM	DFS	Quartile	All	0.201	0.485	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

PIK3IP1–LSCC (DFS)

Open the LSCC breakdown →